Double-control of cytotoxic action of the payload shall serve as a basis for developing safer therapeutic strategies, as schematically outlined below

1

LC-APC bearing photodeactivated payload is safely administered

LC-APC

2

Antibodies interact with tumor-specific antigens and release the payload, sparing the healthy cells

peptide payload, photodeactivated prior to treatment

3

In solid tumors, the peptide is activated with red light, trigering the cytotoxic effect and immune response

higly cytotoxic photoactivated peptide

Principles of potential application of LC-APCs for treatment of cancer.